Activity of anti-inflammatory, analgesic and antigenotoxic of the aqueous flower extracts of Opuntia microdasys Lem.Pfeiff

作者：Chahdoura Hassiba^*; El Bok Safia; Refifa Taoufik; Adouni Khaoula; Khemiss Fethia; Mo**ah Habib; Ben Attia Mossadok; Flamini Guido; Achour Lotfi

来源：Journal of Pharmacy and Pharmacology, 2017, 69(8): 1056-1063.

DOI：10.1111/jphp.12734

• acute toxicity
• analgesic activity
• anti-inflammatory activity
• genoprotective effect
• postflowering stage (F3)
• Opuntia microdasys Lem

ObjectivesThe aim of this study was to evaluate the analgesic and the anti-inflammatory activity of Opuntia microdasys at post flowering stage, F3 (OMF3) in rat and, in other hand, its antigenotoxic effects by the Allium cepa test.
MethodsOMF3 extracts were screened for activity of analgesic and anti-inflammatory using, respectively, the acetic acid writhing test in mice and the carrageenan-induced paw oedema assay in rats. The antigenotoxic has been evaluated by A. cepa test.
Key findingsOMF3 extracts showed a higher analgesic and anti-inflammatory activity at 100 mg/kg (72.03% and 70.11%) as determined by the tests of acetic acid-induced writhing and carrageenan-induced oedema, respectively. Furthermore, the OMF3 aqueous extracts have a preventive antimutagenic potential, at lower concentration (EC50 approximate to 60 g/ml), against H2O2-mediated DNA damage in A. cepa root meristem cells with an efficient restoration of the mitotic index in comparison with controls.
ConclusionsBased on this study, the flower of O. microdasys at post flowering stage may be use as an analgesic, anti-inflammatory and antimutagenic agents.

• 出版日期2017-8