Discovery of a synthetic dual inhibitor of HIV and HCV infection based on a tetrabutoxy-calix[4] arene scaffold

作者：Tsou Lun K; Dutschman Ginger E; Gullen Elizabeth A; Telpoukhovskaia Maria; Cheng Yung Chi^*; Hamilton Andrew D

来源：Bioorganic & Medicinal Chemistry Letters, 2010, 20(7): 2137-2139.

DOI：10.1016/j.bmcl.2010.02.043

• Protein surface recognition
• Calixarenes
• HIV-HCV coinfection inhibitors

A potential anti-HIV and HCV drug candidate is highly desirable as coinfection has become a worldwide public health challenge. A potent compound based on a tetrabutoxy-calix[4] arene scaffold that possesses dual inhibition for both HIV and HCV is described. Structural activity relationship studies demonstrate the effects of lower-rim alkylation in maintaining cone conformation and upper-rim interacting head groups on the calix[4] arene play key roles for its potent dual antiviral activities.

• 出版日期2010-4-1