Double-Filtration Plasmapheresis plus IFN for HCV-1b Patients with Non-Sustained Virological Response to Previous Combination Therapy: Early Viral Dynamics

作者：Kim Soo Ryang^*; Imoto Susumu; Kudo Masatoshi; Mita Keiji; Taniguchi Miyuki; Kim Ke Ih; Sasase Noriko; Shoji Ikuo; Nagano Fujii Motoko; El Shamy Ahmed; Hotta Hak; Nagai Tomoyuki; Nagata Yoshiaki; Hayashi Yoshitake

来源：Intervirology, 2010, 53(1): 44-48.

DOI：10.1159/000252783

• Chronic hepatitis C
• Double-filtration plasmapheresis
• Early viral dynamics
• Genotype 1b
• High viral load
• Interferon beta
• Non-sustained virological responder
• Peginterferon plus ribavirin combination therapy

Double-filtration plasmapheresis (DFPP) was approved in Japan in April 2008 for the retreatment of chronic hepatitis C patients with genotype 1b and high viral loads, whose hepatitis C virus was not eradicated by earlier IFN therapy or by pegylated IFN plus ribavirin (PEG-IFN/RBV) combination therapy. In this study, we assessed the early viral dynamics of 9 patients with non-sustained virological response to the combination therapy. The overall viral dynamics of DFPP plus IFN treatment with or without RBV for 4 weeks showed a reduction of 6 1 log in the viral load in 22% (2 of 9 patients), 55.6% (5/9), 77.8% (7/9) and 77.8% (7/9) at 24 h, 1, 2 and 4 weeks after the start of treatment. By contrast, DFPP plus consecutive intravenous IFN-beta for 4 weeks reduced the viral load by >= 1 log in 33% (2/6), 50% (3/6), 83.3% (5/6) and 83.3% (5/6) at 24 h, 1, 2 and 4 weeks. The viral load declined by >= 2 log in 50% (3/6) at 4 weeks after the start of treatment. DFPP plus consecutive intravenous IFN-beta for 4 weeks is a promising treatment for non-sustained virolgical response patients.

• 出版日期2010