Novel Anterior Brainstem Magnetic Resonance Imaging Findings in Non-Small Cell Lung Cancer with Leptomeningeal Carcinomatosis

作者：Cheng Chun Yu; Hsu Chia Yu; Tsai Yuan Hsiung; Lin Kuang Lin; Huang Cih En; Fan Yi Hong; Chin Shy Chyi; Huang Yen Chu^*

来源：Frontiers in Neurology, 2017, 8: 579.

DOI：10.3389/fneur.2017.00579

• brainstem
• restrictive diffusion
• brain magnetic resonance imaging
• leptomeningeal carcinomatosis
• lung cancer

Leptomeningeal carcinomatosis (LC) is found in around 4% of patients with non-small cell lung cancer (NSCLC). The most common radiological finding of LC is diffuse leptomeningeal enhancement on contrast-enhanced brain magnetic resonance imaging (MRI). Herein, we report a novel brain MRI finding-non-enhanced, band-like, symmetric restricted diffusion along the anterior surface of the brainstem-of LC in four patients with NSCLC. We also identified three additional cases with similar MRI findings in a literature review. We hypothesized that the restricted diffusion along the anterior brainstem was caused by malignant cells concentrating in the cistern around the brainstem and infiltrating into the circumferential perforating arteries along the anterior brainstem surface, which then resulted in microinfarctions.

• 出版日期2017-10-31
• 单位长春大学