Metal-free synthesis of isatin oximes via radical coupling reactions of oxindoles with t-BuONO in water

作者：Wei, Wen-Ting^*; Zhu, Wen-Ming; Ying, Wei-Wei; Wu, Yi; Huang, Yi-Ling; Liang, Hongze

来源：Organic and Biomolecular Chemistry, 2017, 15(25): 5254-5257.

DOI：10.1039/c7ob01235g

• TERT-BUTYL NITRITE
• BECKMANN REARRANGEMENT
• DIRECT CONVERSION
• NITROGEN-SOURCE
• BOND FORMATION
• EFFICIENT
• DERIVATIVES
• STRATEGY
• MILD
• FUNCTIONALIZATION

A metal-free method for the synthesis of isatin oximes was developed through the radical coupling reactions of oxindoles with t-BuONO. This protocol provides a practical and environmentally benign method for the construction of C-N bonds in water at room temperature without using any other reagents. The advantages of this strategy are its mild reaction conditions and clean procedure.

• 出版日期2017-7-7
• 单位宁波大学