Nylon-3 Polymers That Enable Selective Culture of Endothelial Cells

作者:Liu Runhui; Chen Xinyu; Gellman Samuel H*; Masters Kristyn S
来源:Journal of the American Chemical Society, 2013, 135(44): 16296-16299.
DOI:10.1021/ja408634a

摘要

Substrates that selectively encourage the growth of specific cell types are valuable for the engineering of complex tissues. Some cell-selective peptides have been identified from extracellular matrix proteins; these peptides have proven useful for biomaterials-based approaches to tissue repair or regeneration. However, there are very few examples of synthetic materials that display selectivity in supporting cell growth. We describe nylon-3 polymers that support in vitro culture of endothelial cells but do not support the culture of smooth muscle cells or fibroblasts. These materials may be promising for vascular biomaterials applications.

  • 出版日期2013-11-6