Emerging clinical concerns in the ageing haemophilia patient

作者：Konkle B A^*; Kessler C; Aledort L; Andersen J; Fogarty P; Kouides P; Quon D; Ragni M; Zakarija A; Ewenstein B

来源：Haemophilia, 2009, 15(6): 1197-1209.

DOI：10.1111/j.1365-2516.2009.02066.x

• ageing
• comorbidities
• haemophilia

The availability of safe replacement clotting factor concentrates together with effective antiviral drugs to treat human immunodeficiency and hepatitis C viruses and the provision of care at designated haemophilia treatment centres have resulted in a new phenomenon in haemophilia management - the ageing patient. Today, increasing numbers of persons with haemophilia (PWH) are middle-aged and older, and they face the same age-related health issues as the general population. The impact of these risks on PWH is unclear, however, and there is a paucity of information about how to manage comorbidities in this patient population. This review focuses on five comorbidities that uniquely affect older PWH: cardiovascular disease, liver disease, cancer, renal disease and joint disease. Available research is summarized and potential management approaches are suggested.

• 出版日期2009-11
• 单位西北大学