HOME-CAGE ODORS SPATIAL CUES ELICIT THETA PHASE/GAMMA AMPLITUDE COUPLING BETWEEN OLFACTORY BULB AND DORSAL HIPPOCAMPUS

作者：Pena Roberta Ribas; Medeiros Daniel De Castro; Guarnieri Leonardo De Oliveira; Guerra Julio Boriollo; Carvalho Vinicius Rezende; Andrade Marcal Mendes Eduardo Mazoni; Pereira Grace Schenatto; Dutra Moraes Marcio Flavio

来源：Neuroscience, 2017, 363: 97-106.

DOI：10.1016/j.neuroscience.2017.08.058

• familiar odor
• TMT
• olfactory bulb
• hippocampus
• cross-frequency coupling

The brain oscillations may play a critical role in synchronizing neuronal assemblies in order to establish appropriate sensory-motor integration. In fact, studies have demonstrated phase-amplitude coupling of distinct oscillatory rhythms during cognitive processes. Here we investigated whether olfacto-hippocampal coupling occurs when mice are detecting familiar odors located in a spatially restricted area of a new context. The spatial olfactory task (SOT) was designed to expose mice to a new environment in which only one quadrant (target) contains odors provided by its own home-cage bedding. As predicted, mice showed a significant higher exploration preference to the target quadrant; which was impaired by olfactory epithelium lesion (ZnSO4). Furthermore, mice were able to discriminate odors from a different cage and avoided the quadrant with predator odor 2,4,5-trimethylthiazoline (TMT), reinforcing the specificity of the SOT. The local field potential (LFP) analysis of non-lesioned mice revealed higher gamma activity (35-100 Hz) in the main olfactory bulb (MOB) and a significant theta phase/gamma amplitude coupling between MOB and dorsal hippocampus, only during exploration of homecage odors (i.e. in the target quadrant). Our results suggest that exploration of familiar odors in a new context involves dynamic coupling between the olfactory bulb and dorsal hippocampus.

• 出版日期2017-11-5