A(H1N1)pdm09 Vaccination of Health Care Workers: Improved Immune Responses in Low Responders Following Revaccination

作者：Pathirana Rishi Delan; Bredholt Geir; Akselsen Per Espen; Pedersen Gabriel Kristian; Cox Rebecca Jane^*

来源：Journal of Infectious Diseases, 2012, 206(11): 1660-1669.

DOI：10.1093/infdis/jis589

Methods. We analyzed the humoral responses (HI, antibody-secreting cell [ASC], and serum immunoglobulin G [IgG]) in 15 LRs and 25 control HCWs. Twelve LRs were revaccinated with the pH1N1 vaccine, and 7 were subsequently vaccinated with the 2010 seasonal trivalent influenza vaccine. We conducted a long-term analysis of the humoral and CD4(+) T-helper (Th) 1 responses. %26lt;br%26gt;Results. The LRs had a slower HI antibody response than the control HCWs, with protective antibody titers not reached until 2 weeks after vaccination in the majority of the participants. The LRs also had significantly lower IgG ASCs at day 7 and HA1-specific serum IgG responses at day 21, compared with the control HCWs. Revaccination with the pH1N1 vaccine elicited rapid HI antibody, ASC, memory B cell, and multifunctional CD4(+) Th1 cell responses. %26lt;br%26gt;Conclusion. This study shows that revaccination of low-responding HCWs with the pH1N1 vaccine is required for maintaining long-term protection. %26lt;br%26gt;Clinical Trials Registration. NCT01003288.

• 出版日期2012-12-1