A spectroscopic study on the DNA binding behavior of the anticancer drug dacarbazine

作者：Wang XM^*; Li Y; Gong SJ; Fu DA

来源：Spectroscopy Letters, 2002, 35(6): 751-756.

DOI：10.1081/SL-120016277

• dacarbazine
• DNA recognition
• spectroscopic study

The selective binding of some drug to DNA has been explored in this study to elucidate the structure-function relationship of the anticancer agent. In the case of the binding behavior of the anticancer drug dacarbazine [5-(3,3-dimethy-1-triazenyl)imidazole-4-carboxamide; DTIC], it was found that DNA causes significant decrease of the absorption intensity of DTIC without any shift of the peak position. Besides, nuclear magnetic resonance (NMR) study shows that only slight upfield shift was observed upon addition of DNA. These results as well as our nanostructural study by atomic force microscopy (AFM) illustrate the DNA recognition specificity of DTIC though this anticancer drug interacts with DNA by using non-intercalation mode.

• 出版日期2002-11
• 单位东南大学