摘要
Chiral dihydrobenzofuran units are frequently present in molecules with significant biological and pharmaceutical activities. Herein, we present the first enantioselective formal [4+1] annulation of Morita-Baylis-Hillman carbonates with o-quinone methides (o-QMs) catalyzed by a newly designed chiral phosphine catalyst. Under the mild and eco-friendly conditions, a wide range of polysubstituted dihydrobenzofurans were obtained in good yields with excellent enantioselectivities.
- 出版日期2018-12-3
- 单位华东师范大学