Anti-influenza activity of monoterpene-derived substituted hexahydro-2H-chromenes

作者：Patrusheva Oksana S; Zarubaev Vladimir V^*; Shtro Anna A; Orshanskaya Yana R; Boldyrev Sergey A; Ilyina Irina V; Kurbakova Svetlana Yu; Korchagina Dina V; Volcho Konstantin P; Salakhutdinov Nariman F

来源：Bioorganic & Medicinal Chemistry, 2016, 24(21): 5158-5161.

DOI：10.1016/j.bmc.2016.08.037

• Influenza
• Monoterpene
• Antiviral
• Chromene

The antiviral activity of 4-hydroxy-hexahydro-2H-chromenes and 4-fluorine-hexahydro-2H-chromenes with an aromatic substituent, synthesized from monoterpene (-)-verbenone, was studied for the first time. Five of 11 (45 per cent) of 4-hydroxy-hexahydro-2H-chromene-type compounds have been found to exhibit antiviral activity against influenza A virus of subtype H1N1pdm09. Although a portion of active compounds among 4-fluorine-containing series was fewer, just compound 5i that contains a fluorine substituent exhibited more potent anti-influenza activity along with low cytotoxicity. Thus two new promising types of antiviral compounds were identified.

• 出版日期2016-11-1