Designing nanomolar antagonists of DC-SIGN-mediated HIV infection: ligand presentation using molecular rods

作者:Ordanini Stefania; Varga Norbert; Porkolab Vanessa; Thepaut Michel; Belvisi Laura; Bertaglia Andrea; Palmioli Alessandro; Berzi Angela; Trabattoni Daria; Clerici Mario; Fieschi Franck; Bernardi Anna*
来源:Chemical Communications, 2015, 51(18): 3816-3819.
DOI:10.1039/c4cc09709b

摘要

DC-SIGN antagonists were designed combining one selective monovalent glycomimetic ligand with trivalent dendrons separated by a rigid core of controlled length. The design combines multiple multivalency effects to achieve inhibitors of HIV infection, which are active in nanomolar concentration.

  • 出版日期2015
  • 单位中国地震局