Microwave Assisted Synthesis and in vitro Antimicrobial Activities of Fluorine Containing 4-Benzofuran-2-yl-6-phenyl-pyrimidin-2-ylamines

作者：Chundawat Tejpal Singh; Sharma Nutan; Bhagat Sunita^*

来源：Medicinal Chemistry, 2014, 10(4): 409-417.

DOI：10.2174/15734064113099990036

• Claisen-Schmidt condensation
• microwave assisted synthesis
• benzofuran
• pyrimidine
• antimicrobial

A series of new analogs fluorine containing heterocyclic system viz. 4-benzofuran-2-yl-6-phenyl-pyrimidin-2-ylamine has been synthesized and evaluated for in vitro antibacterial and antifungal activities. Microwave assisted Claisen-Schmidt condensation of 2-acetylbenzofuran (3) with fluorinated benzaldehydes (4) afforded corresponding fluorinated chalcones (5a-g). The cyclocondensation of chalcones with guanidine hydrochloride in alkaline media under microwave resulted in the formation of corresponding fluorine containing 4-benzofuran-2-yl-6-phenyl-pyrimidin-2-ylamines (6a-g). All the synthesized compounds have been characterized on the basis of analytical and spectral data and were screened for their antibacterial and antifungal activities. Some of the synthesized compounds showed good antimicrobial activities against bacteria and fungi.

• 出版日期2014-6