Pelvic organ prolapse and collagen-associated disorders

作者：Lammers Karin^*; Lince Sabrina L; Spath Marian A; van Kempen Leon C L T; Hendriks Jan C M; Vierhout Mark E; Kluivers Kirsten B

来源：International Urogynecology Journal and Pelvic Floor Dysfunction, 2012, 23(3): 313-319.

DOI：10.1007/s00192-011-1532-y

• Pelvic organ prolapse
• Collagen
• Heredity
• Varicose veins
• Rectal prolapse
• Joint hypermobility

Pelvic organ prolapse (POP) and other disorders, such as varicose veins and joint hypermobility, have been associated with changes in collagen strength and metabolism. We hypothesized that these various disorders were more prevalent in both POP patients and their family members. %26lt;br%26gt;In this study, the prevalence of various collagen-associated disorders, including POP, was compared between POP patients (n = 110) and control patients (n = 100) and their first and second degree family members. %26lt;br%26gt;POP patients reported a higher prevalence of varicose veins, joint hypermobility and rectal prolapse and were more likely to have family members with POP as compared to the control group (p %26lt; 0.01). In contrast, the family members of the POP group did not report a higher prevalence of collagen-associated disorders compared to the family members of the control group (p = 0.82). %26lt;br%26gt;POP and other collagen-associated disorders may have a common aetiology, originating at the molecular level of the collagens.

• 出版日期2012-3
• 单位河北医科大学