An Efficient Method to Prepare 4-Aminoquinazolines: Potential Application to Conformation-Restricted Bleomycin Analogs

作者：Wei Zhonglin; Zheng Lianyou; Dang Qun^*; Bai Xu

来源：Journal of Heterocyclic Chemistry, 2009, 46(6): 1425-1429.

DOI：10.1002/jhet.238

To enhance the iron-chelating ability of P-3A, 4-aminoquinazolines were designed as conformation-restricted bleomycin analogs. An efficient method was developed to prepare the 4-aminoquinazoline heterocyclic nucleus, which entails a two-step one-pot procedure leading to 4-aminoquinazolines in good yields. The application of this method to synthesis 4-aminoquinazoline bleomycin analogs is envisioned.

• 出版日期2009-11
• 单位吉林大学