Adiponectin and peroxisome proliferator-activated receptor gamma expression in subcutaneous and omental adipose tissue in children

作者：Li Xiaonan^*; Lindquist Susanne; Angsten Gertrud; Yi Jun; Olsson Tommy; Hernell Olle

来源：Acta Paediatrica, 2008, 97(5): 630-635.

DOI：10.1111/j.1651-2227.2008.00715.x

• adiponectin
• adipose tissue
• children
• overweight
• peroxisome proliferator-activated receptor gamma

Aim: To compare the expression levels of the adiponectin and peroxisome proliferator -activated receptor gamma (PPAR gamma) genes in subcutaneous adipose tissue (SC) and omental adipose tissue (OM) in children with relation to age and anthropometric variables.
Methods: Paired biopsies (SC and OM) were obtained from 53 children (age 0.2-14 years, BMI 12.5-25.8 kg/m(2)). Adiponectin and PPAR gamma mRNA levels in adipose tissue were measured by real-time PCR.
Results: In overweight, but not in normal weight children, the median adiponectin mRNA level was significantly lower in OM [0.51 (0.1-2.17)] compared to SC [1.29 (0.16-5.08)], (p = 0.03). Adiponectin mRNA levels were strongly associated with PPAR gamma mRNA levels in both SC (r = 0.73, p < 0.001) and OM (r = 0.78, p < 0.001).
Conclusions: The lower adiponectin expression in OM relative to SC in overweight children indicates that metabolic-endocrine alterations begin already in childhood. The close association between adiponectin and PPAR gamma expression supports the hypothesis this transcription factor is involved in adiponectin gene regulation.

• 出版日期2008-5
• 单位南京医科大学