A novel alternative spliced variant of neutrophil gelatinase-associated lipocalin receptor in oesophageal carcinoma cells

作者：Fang Wang Kai; Xu Li Yan^*; Lu Xiao Feng; Liao Lian Di; Cai Wei Jia; Shen Zhong Ying; Li En Min

来源：Biochemical Journal, 2007, 403: 297-303.

DOI：10.1042/BJ20060836

• iron transport
• lipocalin
• neutrophil gelatinase-associated lipocalin (NGAL)
• NgalR-3
• oesophageal carcinoma

Recent studies suggest that NGAL (neutrophil gelatinase-associated lipocalin) is a novel iron transporter with functions distinct from that of transferrin and mediates a new iron-delivery pathway. To get a better understanding of NGAL function in oesophageal carcinoma, we analysed the expression of NGAL receptors in oesophageal carcinoma cells and identified a novel spliced variant designated NgalR-3. When expressed in a heterologous system, the protein produced from this novel spliced variant exhibits the biochemical characteristics of interaction and co-localization with NGAL protein in vivo. This new finding suggests that NgalR-3 may act as a potential NGAL receptor and play a role in NGAL-mediated iron transport in oesophageal carcinoma.

• 出版日期2007-4-15
• 单位汕头大学