Association between survivin genetic polymorphisms and epidermal growth factor receptor mutation in non-small-cell lung cancer

作者：Liu Tu Chen; Hsieh Ming Ju; Wu Wen Jun; Chou Ying Erh; Chiang Whei Ling; Yang Shun Fa; Su Shih Chi^*; Tsao Thomas Chang Yao^*

来源：International Journal of Medical Sciences, 2016, 13(12): 929-935.

DOI：10.7150/ijms.16875

• non-small-cell lung carcinoma
• survivin
• epidermal growth factor receptor
• genetic variants

Survivin is an anti-apoptotic protein that is implicated in the regulation of apoptosis and cell cycle in various types of cancers. The current study explored the effect of survivin gene polymorphisms and EGFR mutations in non-small-cell lung carcinoma (NSCLC) patients. A total of 360 participants, including 291 adenocarcinoma lung cancer and 69 squamous cell carcinoma lung cancer patients, were selected for the analysis of three survivin genetic variants (survivin -31, +9194, and +9809) by using real-time PCR genotyping. The results indicated that GC+CC genotypes of survivin -31 were significant association with EGFR mutation in lung adenocarcinoma patients (adjusted odds ratio= 3.498, 95% CI = 1.171-10.448; p<0.01). Moreover, The GC+CC genotypes of survivin -31 were associated with EGFR L858R mutation but not in exon 19 in-frame deletions. Furthermore, among patients in exon 19 in-frame deletions, those who have at least one polymorphic G allele of survivin -31 have an increased incidence to develop late-stage when compared with those patients homozygous for C/C (OR, 4.800; 95% CI, 1.305-17.658). In conclusion, our results showed that survivin genetic variants were related to EGFR mutation in lung adenocarcinoma patients and might contribute to pathological development to NSCLC.

• 出版日期2016
• 单位河北医科大学; 中国医科大学