Analyzing a dipeptide library to identify human dipeptidyl peptidase IV inhibitor

作者：Vu Thi Tuyet Lan; Ito Keisuke^*; Ohno Masumi; Motoyama Takayasu; Ito Sohei; Kawarasaki Yasuaki

来源：Food Chemistry, 2015, 175: 66-73.

DOI：10.1016/j.foodchem.2014.11.131

• Human dipeptidyl peptidase IV
• Type 2 diabetes
• Dipeptide
• Functional food

Human dipeptidyl peptidase IV (hDPPIV) inhibitors provide an effective strategy for the treatment of type 2 diabetes. Because certain peptides are known to act as hDPPIV inhibitors, a dataset of possible peptides with their inhibition intensities will facilitate the development of functional food for type 2 diabetes. In this study, we examined a total of 337 dipeptides with respect to their hDPPIV inhibitory effects. Amino acid residues at N-termini dominated their inhibition intensities. Particularly highly inhibitory dipeptides discovered included the following novel dipeptides: Thr-His, Asn-His, Val-Leu, Met-Leu, and Met-Met. Using our dataset, prime candidates contributing to the hDPPIV inhibitory effect of soy protein hydrolyzates were successfully identified. Possible dietary proteins potentially able to produce particularly highly hDPPIV inhibitory peptides are also discussed on the basis of the dataset.

• 出版日期2015-5-15