Diagnostic utility of intravoxel incoherent motion mr imaging in differentiating primary central nervous system lymphoma from glioblastoma multiforme

作者：Yamashita Koji^*; Hiwatashi Akio; Togao Osamu; Kikuchi Kazufumi; Kitamura Yoshiyuki; Mizoguchi Masahiro; Yoshimoto Koji; Kuga Daisuke; Suzuki Satoshi O; Baba Shingo; Isoda Takuro; Iwaki Toru; Iihara Koji; Honda Hiroshi

来源：Journal of Magnetic Resonance Imaging, 2016, 76(5): 1256-1261.

DOI：10.1002/jmri.25261

• intravoxel incoherent motion (IVIM)
• FDG-PET
• glioblastoma
• primary central nervous system lymphoma

PurposeTo evaluate the diagnostic performance of intravoxel incoherent motion (IVIM) MR imaging and F-18-fluorodeoxyglucose positron emission tomography (FDG-PET) in differentiating primary central nervous system lymphoma (PCNSL) from glioblastoma multiforme (GBM).
Materials and MethodsFifty patients, 17 with PCNSL and 33 with GBM, were retrospectively studied. From the 3 Tesla IVIM data, the perfusion fraction (f) and diffusion coefficient (D) were obtained. In addition, the maximum standard uptake value (SUVmax) was obtained from the FDG-PET data. Each of the three parameters was compared between PCNSL and GBM using Mann-Whitney U-test. The performance in discriminating between PCNSL and GBM was evaluated using receiver-operating characteristics analysis and area-under-the-curve (AUC) values for the three parameters.
ResultsThe f(max) and D-min values were significantly higher in GBM than in PCNSL (P < 0.01 and P < 0.0001, respectively). In addition, the SUVmax value was significantly lower in GBM than in PCNSL (P < 0.0005). The AUC values for f(max), D-min, and SUVmax were 0.756, 0.905, and 0.857, respectively. The combination of the f(max) and D-min increased the diagnostic performance (AUC = 0.936) of f(max) (P < 0.05), but this value was not significantly different from the values for D-min (P = 0.30).
ConclusionIVIM-MR imaging noninvasively provides useful quantitative information in distinguishing between PCNSL and GBM. J. Magn. Reson. Imaging 2016;44:1256-1261.

• 出版日期2016-11