Adult T-cell leukemia/lymphoma triggered by adalimumab

作者：Bittencourt Achilea L; Oliveira Pedro D; Bittencourt Valeria G; Carvalho Edgar M; Farre Lourdes^*

来源：Journal of Clinical Virology, 2013, 58(2): 494-496.

DOI：10.1016/j.jcv.2013.07.011

• Adult T-cell leukemia/lymphoma
• Infective dermatitis associated with HTLV-1
• Adalimumab
• Anti-TNF-alpha drugs

Here, we describe a 48-year-old woman infected by the human T-cell lymphotropic virus type 1 (HTLV1) with spondyloarthritis, uveitis, bilateral episcleritis and neurogenic bladder. She had a history of a probable infective dermatitis associated with HTLV-1 (IDH) in childhood. After the use of adalimumab, she developed lymphocytosis and a cutaneous lymphoma associated with IDH. She had the diagnoses of IDH and of chronic adult T-cell leukemia/lymphoma, supported by the demonstration of proviral integration in the cutaneous lesion.

• 出版日期2013-10