A novel pattern based clustering methodology for time-series microarray data

作者：Phan Sieu; Famili Fazel^*; Tang Zoujian; Pan Youlian; Liu Ziying; Ouyang Junjun; Lenferink Anne; O'Connor Maureen Mc Court

来源：International Journal of Computer Mathematics, 2007, 84(5): 585-597.

DOI：10.1080/00207160701203419

• biological pattern recognition
• time-series microarray data
• data mining
• clustering
• co-expressed genes

Identification of co-expressed genes sharing similar biological behaviours is an essential step in functional genomics. Traditional clustering techniques are generally based on overall similarity of expression levels and often generate clusters with mixed profile patterns. A novel pattern recognition method for selecting co-expressed genes based on rate of change and modulation status of gene expression at each time interval is proposed in this paper. This method is capable of identifying gene clusters consisting of highly similar shapes of expression profiles and modulation patterns. Furthermore, we develop a quality index based on the semantic similarity in gene annotations to assess the likelihood of a cluster being a co-regulated group. The effectiveness of the proposed methodology is demonstrated by applying it to the well-known yeast sporulation dataset and an in-house cancer genomics dataset.

• 出版日期2007