Association of IL-18 polymorphisms with rheumatoid arthritis and systemic lupus erythematosus in Asian populations: a meta-analysis

作者：Chen Shuilian; Jiang Feng; Ren Jiangping; Liu Jiajing; Meng Wei^*

来源：BMC Medical Genetics, 2012, 13: 107.

DOI：10.1186/1471-2350-13-107

Background: Interleukin (IL)-18, an important proinflammatory cytokine, plays a potential pathological role in rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE). Studies on the relationship of IL-18 gene promoter rs1946518 (-607A/C) polymorphism, rs187238 (-137G/C) polymorphism with RA and SLE are inconclusive. The aim of this study was to get a more precise estimation of the relationship in Asian populations.
Methods: Meta-analysis was conducted on the associations between the IL-18 (-607A/C and -137G/C) polymorphisms and RA and SLE, using; (1) allele contrast, (2) dominant, and (3) recessive models. A total of 11 studies were included in this study.
Results: For the relationship of IL-18 rs1946518 polymorphism with RA (additive model: OR = 0.752, 95% CI = 0.562-1.006; dominant model: OR = 0.730, 95% CI = 0.479-1.113; recessive model: OR = 0.537, 95% CI = 0.271-1.064) and SLE (additive model: OR = 0.684, 95% CI = 0.455-1.028; dominant model: OR = 0.645, 95% CI = 0.368-1.130; recessive model: OR = 0.672, 95% CI = 0.447-1.010), no significant association with RA and SLE risk can be found under all genetic models in Asian populations. However, significant associations were observed in Chinese population for both RA ((OR = 0.688, 95% CI = 0.532-0.889) and SLE (OR = 0.606, 95% CI = 0.396-0.930) under additive model. For the relationship between IL-18 rs187238 polymorphism and RA or SLE, there was no significant association detected in all genetic models, even in Chinese population.
Conclusions: This meta-analysis indicates that the IL-18-607A/C polymorphism may confer susceptibility to RA and SLE in Chinese population, but not all Asians.

• 出版日期2012-11-15
• 单位复旦大学