A Possible Case of Hepatitis due to Hypereosinophilic Syndrome

作者：Kawamura Tomoe; Hiraoka Atsushi^*; Toshimori Akiko; Ueki Hidetaro; Kaneto Miho; Aibiki Toshihiko; Okudaira Tomonari; Yamago Hiroka; Nakahara Hiromasa; Tomida Hideomi; Suga Yoshifumi; Azemoto Nobuaki; Mori Kenichiro; Miyata Hideki; Ninomiya Tomoyuki; Hirooka Masashi; Abe Masanori; Matsuura Bunzo; Hiasa Yoichi; Kito Katsumi; Michitaka Kojiro

来源：Internal Medicine, 2016, 55(11): 1453-1458.

DOI：10.2169/internalmedicine.55.5982

• acute hepatitis
• eosinophilia
• eosinophilic hepatitis
• hypereosinophilic syndrome

A 63-year-old Japanese man whose white blood cell count and total-bilirubin and aminotransferase levels were elevated was referred to our hospital. Computed tomography did not reveal any abnormalities, and there was no evidence of gastritis or colitis on esophagogastroduodenoscopy. Although the patient had no history of drug use or allergies, a high concentration of eosinophils (80%) was noted. A liver biopsy revealed hepatitis with eosinophilic infiltration. The patient's alanine aminotransferase and eosinophil levels improved with the administration of steroids. A second biopsy, performed 6 months later, showed the improvement of the eosinophilic infiltration. The patient was diagnosed with eosinophilic hepatitis due to the presence of hypereosinophilic syndrome without the dysfunction of other organs.

• 出版日期2016