Development and evaluation of Chitosan nanoparticles based dry powder inhalation formulations of Prothionamide

作者：Debnath Sujit Kumar; Saisivam Srinivasan; Debanth Monalisha; Omri Abdelwahab^*

来源：PLos One, 2018, 13(1): e0190976.

DOI：10.1371/journal.pone.0190976

Prothionamide (PTH), a second line antitubercular drug is used to administer in conventional oral route. However, its unpredictable absorption and frequent administration limit its use. An alternate approach was thought of administering PTH through pulmonary route in a form of nanoparticles, which can sustain the release for several hours in lungs. Chitosan, a bio-degradable polymer was used to coat PTH and further freeze dried to prepare dry powder inhaler (DPI) with aerodynamic particle size of 1.76 mu m. In vitro release study showed initial burst release followed by sustained release up to 96.91% in 24h. In vitro release further correlated with in vivo study. Prepared DPI maintained the PTH concentration above MIC for more than 12h after single dose administration and increased the PTH residency in the lungs tissue more than 24h. Animal study also revealed the reduction of dose in pulmonary administration, which will improve the management of tuberculosis.

• 出版日期2018-1-25
• 单位河北医科大学