A Cool Way to Live Long

作者：Conti Bruno^*; Hansen Malene

来源：Cell, 2013, 152(4): 671-672.

DOI：10.1016/j.cell.2013.01.050

In this issue, Xiao et al. challenge the notion that cold temperatures promote longevity solely through thermodynamic effects. They show that low temperatures activate a cold-sensitive cation channel, TRPA-1, which triggers a complex signaling pathway in both neurons and nonneuronal cells to extend the lifespan of Caenorhabditis elegans.

• 出版日期2013-2-14