Adrenergic signaling in heart failure and cardiovascular aging

作者：Santulli Gaetano; Iaccarino Guido

来源：Maturitas, 2016, 93: 65-72.

DOI：10.1016/j.maturitas.2016.03.022

• Sympathetic nervous system
• Beta adrenergic receptors
• Aging
• Multimorbidity
• Cardiovascular system
• G protein-coupled receptor kinases
• Heart failure

Both cardiovascular disease and aging are associated with changes in the sympathetic nervous system. Indeed, mounting evidence indicates that adrenergic receptors are functionally involved in numerous processes underlying both aging and cardiovascular disorders, in particular heart failure. This article will review the pathophysiological role of the sympathetic nervous system in heart failure and cardiovascular aging.

• 出版日期2016-11