Advances in the Synthesis and Biological Activities of Ocotillol-Type Saponins

作者：Xu Yangrong; Wang Wenzhi; Yang Jingjing; Li Xinli; Meng Qingguo

来源：Chinese Journal of Organic Chemistry, 2016, 36(4): 724-735.

DOI：10.6023/cjoc201510022

• ocotillol-type ginsenoside
• synthesis
• absolute configuration confirmation
• biological activities
• metabolism

Ocotillol-type saponins are a kind of tetracyclic triterpenoid ginsenoside with a tetrahydrofuran ring in the side chain. Ocotillol-type saponins mainly exist in panax plants and possess anti-inflammatory, antibacterial, morphine-antagonistic, neuroprotective, cardioprotective effects, etc. There are less ocotillol-type saponins in natural plants. Recently, many studies on the semi-synthesis, absolute configuration confirmation using X-ray diffraction, effect of anti-myocardial ischemic and metabolism of 20(S)-ocotillol-type saponins have been reported. It was found that 24R-epimer and 24S-epimer had stereoselectivity in anti-ischemic effect and pharmacokinetics. In this paper, the advances of the separation, synthesis, absolute configuration confirmation, pharmacological activity, metabolism of ocotillol-type saponins are reviewed.

• 出版日期2016-4
• 单位烟台大学