Longitudinal association between medication adherence and lung health in people with cystic fibrosis

作者：Eakin Michelle N; Bilderback Andrew; Boyle Michael P; Mogayzel Peter J; Riekert Kristin A^*

来源：Journal of Cystic Fibrosis, 2011, 10(4): 258-264.

DOI：10.1016/j.jcf.2011.03.005

• Adherence
• Cystic fibrosis
• Health outcomes
• Treatment
• Pulmonary exacerbation

Background: This study examined the relationship of medication adherence to frequency of pulmonary exacerbation and rate of decline in FEV1 % predicted (FEV1).
Methods: 95 CF patients aged 6 years or older and prescribed a pulmonary medication, were enrolled in a longitudinal retrospective review of medication adherence and health outcomes (the occurrence and frequency of intravenous (IV) antibiotic treatments and FEV1) over 12-months. Pharmacy refill records were used to calculate a medication possession ratio (MPR).
Results: Composite MPR predicted the occurrence of at least one pulmonary exacerbation requiring a course of IV antibiotics (IRR=2.34, p=0.05), but not the frequency of exacerbations, after controlling for gender, baseline FEV1, and regimen complexity. Composite MPR predicted baseline FEV1 (estimate=29.81, p=.007), but not decline in FEV1.
Conclusions: These results demonstrate a significant relation between medication adherence and IV antibiotics in CF patients, highlighting the importance of addressing adherence during clinic visits to improve health outcomes.

• 出版日期2011-7