Upregulated TCR zeta improves cytokine secretion in T cells from patients with AML

作者：Chen, Shaohua; Zha, Xianfeng; Shi, Li; Zhou, Lingling; Yang, Lijian; Li, Bo; Wu, Xiuli; Zhong, Jun; Zhang, Tao; Lu, Yuhong; Zhu, Kanger; Li, Yangqiu^*

来源：Journal of Hematology & Oncology, 2015, 8(1): 72.

DOI：10.1186/s13045-015-0170-0

• Acute myeloid leukemia
• T cells
• TCR zeta
• Cytokine
• Chemokine

Previous studies indicated that upregulating TCR zeta partially recovers T cell function in patients with leukemia. In this study, we characterized the cytokine profile of TCR zeta-transfected T cells from acute myeloid leukemia (AML) patients by Quantibody (R) Array Glass Chip. Firstly, the significantly lower expression of TCR zeta in CD3(+)/TCR zeta(+) cells from AML patients was found. Increased secretion of IL-2, IL-8, IL-10, IL-13, IFN-gamma, TNF-alpha, GM-CSF, growth-regulated oncogene (GRO), MIP-1b, and regulated on activation, normal T cell expressed and secreted (RANTES) could be detected in T cells from AML patients after TCR zeta upregulating. We concluded that upregulating TCR zeta in T cells from AML can alter the secretion profile of cytokines and chemokine which are involved in T cell proliferation and activation.

• 出版日期2015-6-18
• 单位暨南大学