Design, synthesis and evaluation of seleno-dihydropyrimidinones as potential multi-targeted therapeutics for Alzheimer's disease

作者:Canto Rmulo F S; Barbosa Flavio A R; Nascimento Vanessa; de Oliveira Aldo S; Brighente Ines M C; Braga Antonio Luiz*
来源:Organic and Biomolecular Chemistry, 2014, 12(21): 3470-3477.
DOI:10.1039/c4ob00598h

摘要

In this paper we report the design, synthesis and evaluation of a series of seleno-dihydropyrimidinones as potential multi-targeted therapeutics for Alzheimer's disease. The compounds show excellent results as acetylcholinesterase inhibitors, being as active as the standard drug. All these compounds also show very good antioxidant activity through different mechanisms of action.

  • 出版日期2014