Absolute Configuration of a Rare Sesquiterpene: (+)-3-Ishwarone

作者：Junior Fernando M S; Covington Cody L; de Amorim Mauro B; Velozo Leosvaldo S M; Kaplan Maria A C; Polavarapu Prasad L^*

来源：Journal of Natural Products, 2014, 77(8): 1881-1886.

DOI：10.1021/np500363e

To determine the absolute configuration of 3-ishwarone, the experimental electronic circular dichroism (ECD), electronic dissymmetry factor (EDF), optical rotatory dispersion (ORD), vibrational circular dichroism (VCD), and vibrational dissymmetry factor (VDF) spectra of (+)-3-ishwarone are analyzed with the corresponding density functional theoretical predictions for different diastereomers. ECD and ORD spectra by themselves could not facilitate the determination of the absolute configuration of this molecule. However, the magnitude of the experimental EDF of (+)-3-ishwarone is found to match better with that predicted for the (1R,2S,4S,5R,9R,11R) diastereomer. The analyses of similarity measures between experimental and predicted spectra for VCD and VDF clearly suggested that the absolute configuration of (+)-3-ishwarone is (1R,2S,4S,5R,9R,11R).

• 出版日期2014-8