Analyses of T cell phenotype and function reveal an altered T cell homeostasis in systemic sclerosis Correlations with disease severity and phenotypes

作者：Giovannetti Antonello^*; Rosato Edoardo; Renzi Cristina; Maselli Angela; Gambardella Lucrezia; Giammarioli Anna Maria; Palange Paolo; Paoletti Patrizia; Pisarri Simonetta; Salsano Felice; Malorni Walter; Pierdominici Marina

来源：Clinical Immunology, 2010, 137(1): 122-133.

DOI：10.1016/j.clim.2010.06.004

• Systemic sclerosis
• Lymphocytes
• Apoptosis
• Thymus
• Cell proliferation
• Tregs
• DLCO

We investigated in systemic sclerosis (SSc) patients the T cell homeostasis and its relationship with the clinical course of the disease. Distribution of peripheral T cell subsets, thymic output, lymphocyte proliferation and apoptosis were analyzed by flow cytometry or ELISA. Age inappropriate levels of naive CD4(+) T cells and thymic output were observed. Proliferation of CD4(+) T cells, lymphocyte apoptosis and CD4(+) regulatory T (Treg) cell frequency were significantly higher than those observed in controls and significantly correlated with clinical phenotypes and clinical progression parameters i.e., diffusing capacity of the lung for carbon monoxide (DLCO) and disease activity. These data indicate that the evaluation of the T cell homeostasis can represent a valuable prognostic tool for SSc patients and it is useful to distinguish between limited and diffuse phenotypes. A therapeutic intervention targeted at reversing T cell homeostasis abnormalities would therefore potentially be helpful in counteracting disease progression.

• 出版日期2010-10