A Novel Prioritization Method in Identifying Recurrent Venous Thromboembolism-Related Genes

作者：Jiang, Jing; Li, Wan; Liang, Binhua; Xie, Ruiqiang; Chen, Binbin; Huang, Hao; Li, Yiran; He, Yuehan; Lv, Junjie; He, Weiming^*; Chen, Lina^*

来源：PLos One, 2016, 11(4): e0153006.

DOI：10.1371/journal.pone.0153006

• PROTEIN INTERACTION NETWORK
• CANDIDATE DISEASE GENES
• DIFFERENTIAL EXPRESSION
• TISSUE FACTOR
• D-DIMER
• RISK
• ASSOCIATION
• POLYMORPHISMS
• COAGULATION
• WARFARIN

Identifying the genes involved in venous thromboembolism (VTE) recurrence is important not only for understanding the pathogenesis but also for discovering the therapeutic targets. We proposed a novel prioritization method called Function-Interaction-Pearson (FIP) by creating gene-disease similarity scores to prioritize candidate genes underling VTE. The scores were calculated by integrating and optimizing three types of resources including gene expression, gene ontology and protein-protein interaction. As a result, 124 out of top 200 prioritized candidate genes had been confirmed in literature, among which there were 34 antithrombotic drug targets. Compared with two well-known gene prioritization tools Endeavour and ToppNet, FIP was shown to have better performance. The approach provides a valuable alternative for drug targets discovery and disease therapy.

• 出版日期2016-4-6
• 单位哈尔滨医科大学; 哈尔滨工业大学