microRNA-206 promotes skeletal muscle regeneration and delays progression of Duchenne muscular dystrophy in mice

作者：Liu Ning^*; Williams Andrew H; Maxeiner Johanna M; Bezprozvannaya Svetlana; Shelton John M; Richardson James A; Bassel Duby Rhonda; Olson Eric N

来源：Journal of Clinical Investigation, 2012, 122(6): 2054-2065.

DOI：10.1172/JCI62656

Skeletal muscle injury activates adult myogenic stem cells, known as satellite cells, to initiate proliferation and differentiation to regenerate new muscle fibers. The skeletal muscle-specific microRNA miR-206 is upregulated in satellite cells following muscle injury, but its role in muscle regeneration has not been defined. Here, we show that miR-206 promotes skeletal muscle regeneration in response to injury. Genetic deletion of miR-206 in mice substantially delayed regeneration induced by cardiotoxin injury. Furthermore, loss of miR-206 accelerated and exacerbated the dystrophic phenotype in a mouse model of Duchenne muscular dystrophy. We found that miR-206 acts to promote satellite cell differentiation and fusion into muscle fibers through suppressing a collection of negative regulators of myogenesis. Our findings reveal an essential role for miR-206 in satellite cell differentiation during skeletal muscle regeneration and indicate that miR-206 slows progression of Duchenne muscular dystrophy.

• 出版日期2012-6