A multipurpose Voltammetric Sensor for the Determination of Chlorpromazine in Presence of Acetaminophen, Uric Acid, Dopamine and Ascorbic Acid

作者：Unnikrishnan Binesh^*; Hsu Pei Chi; Chen Shen Ming

来源：International Journal of Electrochemical Science, 2012, 7(11): 11414-11425.

DOI：10.1016/s1452-3981(23)16954-9

• multiwalled carbon nanotube
• polyethyleneimine
• composite
• chlorpromazine
• differential pulse voltammetry

We report the fabrication and characterization of a voltammetric sensor for the determination of chlorpromazine (CPM) based on multiwalled carbon nanotube-polyethyleneimine (MWCNT-PEI) composite modified glassy carbon electrode (GCE). The MWCNT-PEI composite was prepared by a simple ultrasonication method without any pretreatment of MWCNT. CPM shows irreversible oxidation peak at MWCNT and MWCNT-PEI modified GCE in pH 7 at 0.685 V. MWCNT-PEI shows excellent electroanalytical properties towards CPM and can detect as low as 10 nM level by differential pulse voltammetry (DPV) with a sensitivity of 1.3 mu A mu M-1 cm(-2). The MWCNT-PEI film does not show any peak for ascorbic acid. However, it shows well defined and well separate peaks for dopamine, uric acid, acetaminophen and CPM in the same solution. Therefore, this sensor may be used for the determination of all these compounds individually or simultaneously. The fabrication method shows good reproducibility and the film exhibits good stability and appreciable performance in real sample analysis.

• 出版日期2012-11