Acid Suppression Therapy as a Risk Factor for Candida Esophagitis

作者：Kim Kyung Yup; Jang Jae Young^*; Kim Jung Wook; Shim Jae Jun; Lee Chang Kyun; Dong Seok Ho; Kim Hyo Jong; Kim Byung Ho; Chang Young Woon

来源：Digestive Diseases and Sciences, 2013, 58(5): 1282-1286.

DOI：10.1007/s10620-012-2520-x

• Candida
• Esophagitis
• Risk factors
• Histamine H2 antagonists
• Proton pump inhibitors

As the prevalence of reflux esophagitis increases, so does the use of gastric acid suppressants. This study aimed to document the prevalence of Candida esophagitis (CE) at a single Korean university hospital over the last 5 years and to evaluate its risk factors. %26lt;br%26gt;To investigate the prevalence of CE, we conducted a retrospective analysis of 55,314 individuals who underwent a screening esophagogastroduodenoscopy as part of a health check-up between January 2006 and December 2010 at Kyung Hee University Hospital in Seoul, Korea. A total of 250 patients who were treated for CE between January 2008 and August 2011 and 500 age- and sex-matched non-CE patients were enrolled in this study. The rates of recent gastric acid suppression therapy and other well-known risk factors in the two groups were compared. %26lt;br%26gt;The prevalence of CE was 0.35 % and increased each year (linear-by-linear association, P = 0.001). Univariate analysis showed that gastric acid suppression therapy, malignancy, DM and steroid therapy were related to CE. Multivariate analysis also showed that gastric acid suppression therapy (OR 5.11, 95 % CI 2.92-8.93 and P %26lt; 0.001), malignancy (OR 18.68, 95 % CI 6.37-54.75 and P %26lt; 0.001), DM (OR 2.67, 95 % CI 1.70-4.21 and P %26lt; 0.001) and steroids therapy (OR 6.74, 95 % CI 1.37-33.05 and P = 0.019) were related to CE. %26lt;br%26gt;The prevalence of CE in Korea is increasing. Also, our results indicate that acid suppression therapy is a meaningful risk factor for CE.

• 出版日期2013-5