A new anti-diabetic sesquiterpenoid from Acorus calamus

作者：Zhou, Chang Xin; Qiao, Di; Yan, You You; Wu, Hao Shu; Mo, Jian Xia; Gan, Li She^*

来源：Chinese Chemical Letters, 2012, 23(10): 1165-1168.

DOI：10.1016/j.cclet.2012.08.004

• Acorus calamus
• 1 beta,5 alpha-Guaiane-4 beta,10 alpha-diol-6-one
• TDDFF
• Anti-diabetic activity

A new sesquiterpenoid, 1 beta,5 alpha-guaiane-4 beta,10 alpha-diol-6-one (1), was isolated from 70% EtOH extract of the rhizomes of Acorus calamus. The structure was determined on spectroscopic methods, especially 2D NMR techniques. The absolute configuration of 1 was confirmed by TDDFT quantum chemical calculation of its ECD spectrum. Compound 1 showed promising anti-diabetic activity on a insulin-mediated glucose consumption model of HepG2 cells.

• 出版日期2012-10
• 单位浙江大学