Gold nanoparticle-mediated gene delivery induces widespread changes in the expression of innate immunity genes

作者：Kim E Y; Schulz R; Swantek P; Kunstman K; Malim M H; Wolinsky S M^*

来源：Gene Therapy, 2012, 19(3): 347-353.

DOI：10.1038/gt.2011.95

• gold nanoparticle-oligonucleotide complexes
• gene delivery
• gene expression
• signaling pathways
• immune activation

The unique properties of oligonucleotide (and small interfering RNA)-modified gold nanoparticle conjugates make them promising intracellular gene regulation agents. We found that gold nanoparticles stably functionalized with covalently attached oligonucleotides activate immune-related genes and pathways in human peripheral blood mononuclear cells, but not an immortalized, lineage-restricted cell line. These findings have strong implications for the application of oligonucleotide-modified gold nanoparticle conjugates in translational research and in the development of therapeutics and gene delivery systems. Gene Therapy (2012) 19, 347-353; doi:10.1038/gt.2011.95; published online 23 June 2011

• 出版日期2012-3
• 单位西北大学