ASSOCIATION OF EXOTOXIN-PRODUCING GROUP-A STREPTOCOCCI AND SEVERE DISEASE IN CHILDREN

作者：BELANI K; SCHLIEVERT PM; KAPLAN EL; FERRIERI P

来源：Pediatric Infectious Disease Journal, 1991, 10(5): 351-354.

DOI：10.1097/00006454-199105000-00001

• TOXIN-PRODUCING GROUP-A STREPTOCOCCI
• GROUP-A STREPTOCOCCUS
• STREPTOCOCCAL TOXIC SHOCK
• STREPTOCOCCAL TOXINS

Clinical features and microbiologic data on all cases of serious (hospitalized) Group A streptococcal infections in children managed at our institution between 1985 and 1988 are presented. All 6 cases were caused by toxin-producing strains. Four of 6 were toxin A-producing strains whereas none of 58 community-acquired (Group A streptococcal) pharyngeal isolates in the same period was a toxin A producer. A review of the literature on the incidence of toxin A-producing strains provides information suggesting a resurgence of such strains in the late 1980s after a relative disappearance in the preceding 30 years. The incidence of toxin B production in isolates from these patients was also significantly greater than in the isolates acquired from the community in uncomplicated pharyngitis. These findings suggest a role for exotoxin in severe manifestations of Group A streptococcal disease in children.

• 出版日期1991-5