Acute lymphoblastic leukemia with T+PH1 monocytosis: a case report

作者：Jmili Nejia Braham^*; Sendi Halima; Khelif Abderrahim

来源：Annales de Biologie Clinique, 2011, 69(4): 473-475.

DOI：10.1684/abc.2011.0595

• karyotype
• Philadelphia chromosome
• immunophenotype
• acute lymphoblastic leukemia

Acute lymphoblastic leukemia Type T PH1 positive (with t (9.22)) are exceptional. These effects can occur immediately or in the evolution of chronic myeloid leukemia known. We report the case of a patient aged 31 years with acute lymphoblastic leukemia T PH1 + cyologiques with cytological atypia. The overall appearance of blood and marrow: the signs of dysplasia the presence of a monocytic contingent, with blood monocytes evoked a myeloid acute leukemia AL. But the immunophenotype was unequivocally in favor of T-acute lymphoblastic leukemia with one aspect of lymphoid blasts in morphology and myeloperoxidase negative. The karyotype showed the presence of Philadelphia chromosome in all mitoses with additional abnormalities (chromosomes 2, 11, 16...).

• 出版日期2011-8