A Baker-Venkataraman retro-Claisen cascade delivers a novel alkyl migration process for the synthesis of amides

作者：Ameen Dana; Snape Timothy J^*

来源：Tetrahedron Letters, 2015, 56(14): 1816-1819.

DOI：10.1016/j.tetlet.2015.02.077

• Baker-Venkataraman
• retro-Claisen
• Rearrangement
• Amide

A simple extension of the carbamoyl Baker-Venkataraman rearrangement has been developed. If residual water in the reaction is not strictly excluded a Baker-Venkataraman retro-Claisen cascade takes place, giving amide products, in which an alkyl group apparently migrates between two functionalities of the substrate.

• 出版日期2015-4-1