Autoimmunity in picornavirus infections

作者：Massilamany Chandirasegaran; Koenig Andreas; Reddy Jay; Huber Sally; Buskiewicz Iwona^*

来源：Current Opinion in Virology, 2016, 16: 8-14.

DOI：10.1016/j.coviro.2015.10.004

Ehteroviruses are small, non-enveloped, positive-sense single strand RNA viruses, and are ubiquitously found throughout the world. These viruses usually cause asymptomatic or mild febrile illnesses, but have a propensity to induce severe diseases including type 1 diabetes and pancreatitis, paralysis and neuroinflammatory disease, myocarditis, or hepatitis. This pathogenicity may result from induction of autoimmunity to organ-specific antigens. While enterovirus-triggered autoimmunity can arise from multiple mechanisms including antigenic mimicry and release of sequestered antigens, the recent demonstration of T cells expressing dual T cell receptors arising as a natural consequence of Theiler's virus infection is the first demonstration of this autoimmune mechanism.

• 出版日期2016-2