科研之友
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摘要
Background: GMZ2 is a fusion protein of Plasmodium falciparum merozoite surface protein 3 (MSP3) and glutamate rich protein (GLURP) that mediates an immune response against the blood stage of the parasite. Two previous phase I clinical trials, one in naive European adults and one in malaria-exposed Gabonese adults showed that GMZ2 was well tolerated and immunogenic. Here, we present data on safety and immunogenicity of GMZ2 in one to five year old Gabonese children, a target population for future malaria vaccine efficacy trials Methodology/Principal Findings: Thirty children one to five years of age were randomized to receive three doses of either 30 mu g or 100 mu g of GMZ2, or rabies vaccine. GMZ2, adjuvanted in aluminum hydroxide, was administered on Days 0, 28 and 56. All participants received a full course of their respective vaccination and were followed up for one year. Both 30 mu g and 100 mu g GMZ2 vaccine doses were well tolerated and induced antibodies and memory B-cells against GMZ2 as well as its antigenic constituents MSP3 and GLURP. After three doses of vaccine, the geometric mean concentration of antibodies to GMZ2 was 19-fold (95% CI: 11,34) higher in the 30 mu g GMZ2 group than in the rabies vaccine controls, and 16-fold (7,36) higher in the 100 mu g GMZ2 group than the rabies group. Geometric mean concentration of antibodies to MSP3 was 2.7-fold (1.6,4.6) higher in the 30 mu g group than in the rabies group and 3.8-fold (1.5,9.6) higher in the 100 mu g group. Memory B-cells against GMZ2 developed in both GMZ2 vaccinated groups. Conclusions/Significance: Both 30 mu g as well as 100 mu g intramuscular GMZ2 are immunogenic, well tolerated, and safe in young, malaria-exposed Gabonese children. This result confirms previous findings in naive and malaria-exposed adults and supports further clinical development of GMZ2.
- 出版日期2011-7-28
