科研之友
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摘要
Acute encephalopathy is a disease group more commonly seen in children. It is often severe and has neurological sequelae. Imaging is important for early diagnosis and prompt treatment to ameliorate an unfavorable outcome, but insufficient sensitivity/specificity is a problem. To overcome this, a new value (fraction of high b-pair (F-H)) that could be processed from clinically acceptable MR diffusion-weighted imaging (DWI) with three different b-values was designed on the basis of a two-compartment model of water diffusion signal attenuation. The purpose of this study is to compare F-H with the apparent diffusion coefficient (ADC) regarding the detectability of pediatric acute encephalopathy. We retrospectively compared the clinical DWI of 15 children (1-10 years old, mean 2.34, 8 boys, 7 girls) of acute encephalopathy with another 16 children (1-11 years old, mean 4.89, 9 boys, 7 girls) as control. A comparison was first made visually by mapping F-H on the brain images, and then a second comparison was made on the basis of 10 regions of interest (ROIs) set on cortical and subcortical areas of each child. F-H map visually revealed diffusely elevated F-H in cortical and subcortical areas of the patients with acute encephalopathy; the changes seemed more diffuse in F-H compared to DWI. The comparison based on ROI revealed elevated mean F-H in the cortical and subcortical areas of the acute encephalopathy patients compared to control with significant difference (P%26lt;0.05). Similar findings were observed even in regions where the findings of DWI were slight. The reduction of mean ADC was significant in regions with severe findings in DWI, but it was not constant in the areas with slighter DWI findings. The detectability of slight changes of cortical and subcortical lesions in acute encephalopathy may be superior in F-H compared to ADC.
- 出版日期2013-6-3
