Angiogenin Defines Heterogeneity at the Core of the Hematopoietic Niche

作者:Di Scala Marianna; Hidalgo Andres*
来源:Cell Stem Cell, 2016, 19(3): 284-286.
DOI:10.1016/j.stem.2016.08.017

摘要

Successful hematopoietic regeneration demands preservation of stemness while enabling expansion and differentiation into blood lineages. Now, Silberstein et al. (2016) and Goncalves et al. (2016) identify a ribonuclease secreted by proximal niche cells that simultaneously drives quiescence of HSCs and proliferation of myeloid progenitors and dramatically enhances hematopoietic recovery after HSC transplantation.

  • 出版日期2016-9-1