Down-regulation of miR-129-5p via the Twist1-Snail feedback loop stimulates the epithelial-mesenchymal transition and is associated with poor prognosis in breast cancer

作者：Yu, Yue; Zhao, Ying; Sun, Xiao-Hu; Ge, Jie; Zhang, Bin; Wang, Xin; Cao, Xu-Chen^*

来源：Oncotarget, 2015, 6(33): 34423-34436.

DOI：10.18632/oncotarget.5406

• miR-129-5p
• Twist1
• Snail
• EMT
• breast cancer progression

The epithelial to mesenchymal transition (EMT) plays a pivotal role in breast cancer progression. We found that overexpression of miR-129-5p reversed EMT, whereas depletion of miR-129-5p induced EMT in breast cancer cells. We demonstrated that Twist1 is a direct target of miR-129-5p. Both Twist1 and Snail transcriptionally suppressed miR-129-5p expression. Levels of miR-129-5p were low in breast cancer tissues. miR-129-5p down-regulation correlated with advanced clinical stage and poor prognosis in patients with breast cancer. miR-129-5p expression negatively correlated with Twist1 and Snail expression. Thus, miR-129-5p down-regulation fosters EMT in breast cancer by increasing Twist1-Snail and activating a negative feedback loop.

• 出版日期2015-10-27
• 单位天津医科大学