Association between CLOCK 3111T/C and preferred circadian phase in Korean patients with bipolar disorder

作者：Lee Kyu Young; Song Joo Yun; Kim Se Hyun; Kim Seong Chan; Joo Eun Jeong; Ahn Yong Min; Kim Yong Sik^*

来源：Progress in Neuro-Psychopharmacology and Biological Psychiatry, 2010, 34(7): 1196-1201.

DOI：10.1016/j.pnpbp.2010.06.010

• Age at onset
• Bipolar disorder
• CLOCK
• Korean
• Morningness/eveningness

Genes associated with circadian rhythms have been suggested to play an important role in the pathophysiology of bipolar disorder A single nucleotide polymorphism (SNP) in the 3'-flanking region of CLOCK (3111T/C, rs1801260) has been reported to be associated with sleep disturbances and an increased recurrence rate in patients with bipolar disorder. We examined the association of CLOCK 3111T/C with bipolar disorder in 260 patients and 350 controls in a Korean population CLOCK 3111T/C showed significant allelic and genotypic associations with bipolar disorder (P=0.012, P=0 033, respectively) Morningness/eveningness (M/E) was evaluated using the Composite Scale of Morningness (CSM) in 108 patients with bipolar disorder In the subgroup analysis of the highest and lowest 25th percentile of M/E scores, significantly more C allele carriers were found among extreme evening types than among extreme morning types (P= 0.041) After correcting for age. C allele carriers had lower M/E scores than those carrying the T/T genotype, but the association was not statistically significant We also analyzed the association between age at onset (AAO) and CLOCK 3111T/C in the bipolar disorder group, and no association was found Despite the relatively small sample sizes, these results support a possible role of the CLOCK 3111T/C SNP in bipolar disorder.

• 出版日期2010-10-1