Determination of the Lipophilicity of Some New Derivatives of Semicarbazide and 1,2,4-Triazol-5-one with Potential Antibacterial Activity

作者：Pitucha Monika^*; Polak Beata; Swieboda Ryszard; Kosikowska Urszula; Malm Anna

来源：Zeitschrift fur Naturforschung Section B-A Journal of Chemical Sciences, 2009, 64(5): 570-576.

DOI：10.1515/znb-2009-0514

• Semicarbazide
• 1,2,4-Triazol-5-one
• Lipophilicity
• Antibacterial Activity

The chromatographic behavior of new derivatives of 1,2,4-triazol-5-one and semicarbazide was determined. The lipophilicity was confirmed by the use of a RP-TLC method. The partition coefficients were calculated by use of theoretical procedures. The correlation between theoretical and experimental lipophilicity was determined. All obtained compounds were tested for their antimicrobial activity.

• 出版日期2009-5